Proteins therapeutics are well established as a clinically and commercially important class of new medicines. Our deep experience in protein engineering has provided a better understanding of their strengths and limitations, leading to new technologies to improve and develop better protein drugs. Protelica is developing the next generation of protein therapeutics called Pronectins™ which is a new format of engineered protein scaffolds. The development of Pronectins™ will take advantage of the enhanced antibodies, such as optimized Fc fusion proteins, bispecific and antibody drug conjugates in early clinical development. Pronectins™ will feature many advantages over antibodies with enhancements related to more efficacy, greater safety, no immunogenicity or improved delivery.
Pronectin™ therapeutic products offer the following features:
• High affinity, specific binding to a therapeutic target with only a single Pronectin domain
• Enhanced efficacy with greater potential to specifically modulate multiple therapeutic targets for multiple therapeutic effects in a single drug molecule
• No immunogenicity potential: the Pronectin backbone is designed from a naturally occurring human fibronectin protein that has evolved to be tolerated by the human immune system
• Broad therapeutic applications by creating Pronectins™ to many target types, including targets that are hard to drug by antibodies or small molecules.
Pronectin™ therapeutic products offer the following features:
• High affinity, specific binding to a therapeutic target with only a single Pronectin domain
• Enhanced efficacy with greater potential to specifically modulate multiple therapeutic targets for multiple therapeutic effects in a single drug molecule
• No immunogenicity potential: the Pronectin backbone is designed from a naturally occurring human fibronectin protein that has evolved to be tolerated by the human immune system
• Broad therapeutic applications by creating Pronectins™ to many target types, including targets that are hard to drug by antibodies or small molecules.
